How Your Immune System Works & How to Improve It | Dr. Max Krummel
My guest is Dr. Matthew (Max) Krummel, PhD, professor at UCSF and one of the world’s leading immunologists. We discuss how your immune system works and how sleep, emotions, and even memories shape immune function. We also explore thymus function, its role in autoimmunity, and its potential role in combating cancer. And we discuss how the type and timing of immunization can impact health. This episode provides an actionable framework for understanding how your immune system works, which ought to benefit people of all ages and health statuses.
Articles
- CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation (The Journal of Experimental Medicine)
- Enhancement of antitumor immunity by CTLA-4 blockade (Science)
- Insular cortex neurons encode and retrieve specific immune responses (Cell)
- Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer (Cell Stem Cell)
- The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring (Science)
- Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour (Nature)
Books
Other Resources
The Immune Beyond (Max’s Substack)
- Your First Five Years Set Your Immune System Up for Life
- A Brief History of Checkpoint Blockade
- New Immunity
- Vaccination: The Origin Story
- Big Breakthrough, Tragic Timing
Huberman Lab Episodes Mentioned
- Avoiding, Treating & Curing Cancer With the Immune System | Dr. Alex Marson
- Improving Science & Restoring Trust in Public Health | Dr. Jay Bhattacharya
- Dr. Bernardo Huberman: How to Use Curiosity & Focus to Create a Joyful & Meaningful Life
People Mentioned
- James Allison: cancer immunologist, Nobel laureate
- Jacques Miller: immunologist, discovered thymus function
- Alexander Marson: professor of medicine, UCSF
- David Feldheim: professor of molecular, cell and developmental biology, UC Santa Cruz
- Sofie Salama: professor of molecular, cell and developmental biology, UC Santa Cruz
- Randy Schekman: professor of molecular and cell Biology, UC Berkeley, Nobel laureate
- Carla Shatz: professor of biology and neurobiology, Stanford University
- Ben Barres: professor of neurobiology, Stanford University
- Beth Stevens: professor of neurology, Harvard Medical School
- Cagla Eroglu: professor of cell biology and neurobiology, Duke University
- Elly Tanaka: Regeneration biologist, Research Institute of Molecular Pathology
About this Guest
Dr. Max Krummel
Matthew (Max) Krummel, PhD, is a professor of pathology at the University of California, San Francisco, and a pioneer of cancer immunotherapy.
This transcript is currently under human review and may contain errors. The fully reviewed version will be posted as soon as it is available.
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