Avoiding, Treating & Curing Cancer With the Immune System | Dr. Alex Marson
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Dr. Alex Marson, MD, PhD, is a professor of medicine at the University of California, San Francisco. We discuss the biology of the immune system and cancer, and everyday choices that can increase or decrease your cancer risk, several of which are surprising but all of which are actionable. We also discuss immunotherapy, including how engineered T-cells can be used to defeat childhood and adult cancers. Dr. Marson explains CRISPR and gene editing to cure diseases, and we address the ethical questions surrounding gene editing in embryos, children and adults. This discussion is for anyone interested in avoiding cancer and/or seeking to understand the science and practical applications of immune- or gene-therapy.
Articles
- Obesity alters pathology and treatment response in inflammatory disease (Nature)
- Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy (New England Journal of Medicine)
- Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia (New England Journal of Medicine)
- A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity (Science)
- Generation of knock-in primary human T cells using Cas9 ribonucleoproteins (Proceedings of the National Academy of Sciences)
- Reprogramming human T cell function and specificity with non-viral genome targeting (Nature)
- Genetic enhancement of learning and memory in mice (Nature)
Books
- The Emperor of All Maladies: A Biography of Cancer
- The Case against Perfection: Ethics in the Age of Genetic Engineering
Other Resources
- The Human Genome Project
- CRISPR
- Arsenal Bio
- Gladstone-UCSF Institute of Genomic Immunology
- Amgen
- Chinese Scientist Who Says He Edited Babies' Genes Defends His Work (The New York Times)
- Orchid
Huberman Lab Episodes Mentioned
People Mentioned
- Jennifer Doudna: professor, UC Berkeley; Nobel laureate
- Emmanuelle Charpentier: director, Max Planck Institute; Nobel laureate
- David Liu: professor of natural sciences, Harvard University
- Walter Issacson: journalist, author
- Shinya Yamanaka: investigator, Gladstone Institutes; Nobel laureate
About this Guest
Dr. Alex Marson
Alex Marson, MD, PhD, is a professor of medicine at University of California, San Francisco.
This transcript is currently under human review and may contain errors. The fully reviewed version will be posted as soon as it is available.
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