How Mitochondria Control Your Metabolism | Dr. Jared Rutter
Dr. Jared Rutter, PhD, Professor of Biochemistry at the University of Utah and Howard Hughes Medical Institute Investigator, is a leading expert on mitochondria and metabolism. He explains how mitochondria produce the energy for your cells to work but also how they regulate cell growth and replication and thereby contribute to health and disease. We also discuss how mitochondria are linked to aging, cancer, and other diseases. Our conversation explores your metabolism as the composite of trillions of individual cells and points to new ways to improve health, avoid, and treat diseases.
Articles
- Cellular ATP demand creates metabolically distinct subpopulations of mitochondria (Nature)
- mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis (The Journal of Cell Biology)
- Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism (Nature Cell Biology)
- A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans (Science)
- Identification and functional expression of the mitochondrial pyruvate carrier (Science)
- The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure (Cell Metabolism)
- Mitochondrial pyruvate carriers are required for myocardial stress adaptation (Nature Metabolism)
- Glucose feeds the TCA cycle via circulating lactate (Nature)
- Allograft theory: transmission of devil facial-tumour disease (Nature)
- Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum (ACS Central Science)
Other Resources
Huberman Lab Episodes Mentioned
- How Your Immune System Works & How to Improve It | Dr. Max Krummel
- Dr. Andy Galpin: How to Build Physical Endurance & Lose Fat
- Behaviors That Alter Your Genes to Improve Your Health & Performance | Dr. Melissa Ilardo
- Dr. David Fajgenbaum: Using Drugs to Treat Diseases of the Brain & Body
People Mentioned
- Justin Sonnenburg: Professor of Microbiology and Immunology, Stanford University
- Mario Capecchi: Professor of Human Genetics, University of Utah
- Otto Warburg: physiologist, Nobel laureate
About this Guest
Dr. Jared Rutter
Jared Rutter, PhD, is a Professor of Biochemistry at the University of Utah and Howard Hughes Medical Institute Investigator, and a leading expert on mitochondria and metabolism.
This transcript is currently under human review and may contain errors. The fully reviewed version will be posted as soon as it is available.
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