Restore Youthfulness & Vitality to the Aging Brain & Body | Dr. Tony Wyss-Coray
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Dr. Tony Wyss-Coray, PhD, is a professor of neurology at Stanford School of Medicine who is discovering factors present in young blood and in exercised blood that can improve brain, heart and other organ health. We discuss how different organs age at different rates and how to accurately measure biological aging. We also discuss the specific proteins found in blood when we are young and that are increased by things such as exercise, sunlight exposure, short-term fasting, specific foods and social connection that can significantly increase vitality, restore youthful functioning of the brain and body and potentially increase lifespan.
Articles
- The ageing systemic milieu negatively regulates neurogenesis and cognitive function (Nature)
- Undulating changes in human plasma proteome profiles across the lifespan (Nature Medicine)
- Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins (Nature Medicine)
- A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer's disease: Primary results of the AMBAR Study (Alzheimer's & Dementia)
- Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange (Aging Cell)
- Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans (Nature)
- Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim (GeroScience)
- Avoidance of sun exposure as a risk factor for major causes of death: a competing risk analysis of the Melanoma in Southern Sweden cohort (Journal of Internal Medicine)
- A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease (Nature Medicine)
- Sport and longevity: an observational study of international athletes (GeroScience)
- An exercise-inducible metabolite that suppresses feeding and obesity (Nature)
- The will to persevere induced by electrical stimulation of the human cingulate gyrus (Neuron)
- Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (The Lancet)
- Day and night light exposure are associated with psychiatric disorders: an objective light study in >85,000 people (Nature Mental Health)
- Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease (bioRxiv)
Books
- Spark: The Revolutionary New Science of Exercise and the Brain
- The Longevity Diet: Slow Aging, Fight Disease, Optimize Weight
- Why We Sleep: Unlocking the Power of Sleep and Dreams
Other Resources
Huberman Lab Episodes Mentioned
- Using Existing Drugs in New Ways to Treat & Cure Diseases of Brain & Body | Dr. David Fajgenbaum
- Dr. Shanna Swan: How to Safeguard Your Hormone Health & Fertility
People Mentioned
- David Sinclair: Professor of Genetics, Harvard Medical School
- Valter Longo: Professor of Gerontology and Biological Sciences, University of Southern California
- Teo Soleymani: board-certified dermatologist, skin cancer specialist

About this Guest
Dr. Tony Wyss-Coray
Tony Wyss-Coray, PhD, is a professor of neurology at Stanford School of Medicine, who uses blood-based biomarkers to evaluate organ health and disease risk.
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