Using Existing Drugs in New Ways to Treat & Cure Diseases of Brain & Body | Dr. David Fajgenbaum
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My guest is Dr. David Fajgenbaum, MD, professor of translational medicine and human genetics at the University of Pennsylvania. He explains how, unbeknownst to most doctors, many approved medications can successfully treat or even cure diseases other than the ones they are typically used to treat. He shares his story of escaping death from Castleman's disease by discovering a life-saving treatment using repurposed drugs that were approved for other purposes. Our conversation explores how researchers, physicians, and you—the general public—can explore novel treatments and cures to conditions the medical profession has deemed untreatable, including cancers. We also discuss the crucial role of mindset in battling diseases and the lesser-known use of compounds to promote health and longevity.
Articles
- Effect of Peritumoral Infiltration of Local Anesthetic Before Surgery on Survival in Early Breast Cancer (Journal of Clinical Oncology)
- Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival (The New England Journal of Medicine)
- Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction (The New England Journal of Medicine)
- Colchicine in Patients with Chronic Coronary Disease (The New England Journal of Medicine)
- Angiosarcoma treated successfully with anti-PD-1 therapy – a case report (Journal for ImmunoTherapy of Cancer)
- Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals (Cell)
- TNF inhibition in vasculitis management in adenosine deaminase 2 deficiency (DADA2) (Journal of Allergy and Clinical Immunology)
- Identifying and Targeting TNF Signaling in Idiopathic Multicentric Castleman’s Disease (The New England Journal of Medicine)
- Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease (eLife)
Books
- Chasing My Cure: A Doctor's Race to Turn Hope into Action; A Memoir
- The Comfort Crisis: Embrace Discomfort To Reclaim Your Wild, Happy, Healthy Self
Every Cure Resources
- Every Cure
- Drug Repurposing Portfolio
- Partner with Every Cure
- Expert Volunteering for Every Cure
- Donate to Every Cure
- Every Cure Newsletter
Other Resources
- OpenEvidence
- Castleman Disease Collaborative Network
- ALS Association
- Michael J. Fox Foundation
- The Dirty Drug and the Ice Cream Tub (Radiolab)
Huberman Lab Episodes Mentioned
- Dr. Eddie Chang: The Science of Learning & Speaking Languages
- How to Grow From Doing Hard Things | Michael Easter
- Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy
People Mentioned
- Benjamin Castleman: professor of pathology Harvard Medical School, described Castleman’s disease
- Chip Chambers: physician advocate, DADA2 Foundation
- Luke Chen: Professor, Department of Medicine, University of British Columbia
- Kazu Yoshizaki: Professor of Immuno-Medical Science, Osaka University, Japan
- Josef Parvizi: professor of neurology, Stanford University
- Grant Mitchell: co-founder of Every Cure
- Tracey Sikora: co-founder of Every Cur
About this Guest
Dr. David Fajgenbaum
David Fajgenbaum, MD, is a professor of translational medicine and human genetics at the University of Pennsylvania.
This transcript is currently under human review and may contain errors. The fully reviewed version will be posted as soon as it is available.
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