Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
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In this Huberman Lab Essentials episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging.
We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body's natural longevity pathways. This discussion highlights how lifestyle choices profoundly influence the aging process and may even slow or reverse key aspects of biological aging.
Articles
- The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size (The Journal of Nutrition)
- Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function (Nature Medicine)
- Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype (Nature Metabolism)
- NAD+ Repletion Rescues Female Fertility during Reproductive Aging (Cell Reports)
People Mentioned
- Clive McCay: biochemist, nutritionist
- Ana Maria Cuervo: professor of developmental and molecular biology, Albert Einstein College of Medicine
- Manuel Serrano: Principal Investigator, Altos Labs Cambridge Institute of Science
This transcript is currently under human review and may contain errors. The fully reviewed version will be posted as soon as it is available.
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Dr. David Sinclair: The Biology of Slowing & Reversing Aging
Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes.
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