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October 23, 2025

Essentials: The Science of Gratitude & How to Build a Gratitude Practice

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In this Huberman Lab Essentials episode, I explore the science of gratitude and how to develop an effective, research-supported gratitude practice.

I explain why common gratitude practices (like simply listing things you're grateful for) are far less impactful than engaging in story-based gratitude practices. I also explain how being grateful activates specific brain regions, which enhance calm, social connection and motivation, while reducing anxiety and inflammation. Finally, I share why we can't simply trick our brains into feeling grateful and describe a practical weekly gratitude practice that will improve both your mental and physical well-being.

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Huberman Lab Episodes Mentioned

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  • 00:00:00 Gratitude
  • 00:00:30 Gratitude Practice Benefits
  • 00:03:22 Pro-Social vs Defensive Behaviors, Gratitude
  • 00:06:25 Serotonin, Brain & Context; Gratitude Mindset
  • 00:12:21 Context, Can You Lie to Yourself?
  • 00:13:06 Effective Gratitude Practice, Tools: Receiving Gratitude, Story
  • 00:19:36 Tool: Find & Revisit Inspirational Stories
  • 00:24:19 Heartfelt Intention, Genuine Thanks
  • 00:26:31 Gratitude Practice Benefits for Anxiety, Fear & Motivation
  • 00:28:58 Gratitude Practice Benefits for Immune System
  • 00:31:31 Recap: Establishing an Effective Gratitude Practice

This transcript is currently under human review and may contain errors. The fully reviewed version will be posted as soon as it is available.

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Huberman Lab Essentials

The Science of Gratitude & How to Build a Gratitude Practice

Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes.

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