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August 28, 2025

Essentials: Effects of Fasting & Time Restricted Eating on Fat Loss & Health

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In this Huberman Lab Essentials episode, I explore intermittent fasting and time-restricted eating, highlighting the positive benefits for weight loss, metabolism, organ health, circadian rhythms and cellular repair.

I explain a practical framework for designing a time-restricted eating window that aligns with your lifestyle, exercise schedule and social schedule. I also cover what breaks a fast, how to support fasting with tools like salt intake and post-meal walks, and the use of fasting-related supplements, including berberine and metformin.

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  • 00:00:00 Intermittent Fasting, Time-Restricted Eating (TRE)
  • 00:00:50 Diet, Weight Loss, Calories & Hormones
  • 00:05:52 Body’s Response to Eating vs Fasting, Fasting Duration
  • 00:09:04 Time-Restricted Feeding & Metabolic Benefits, Circadian Gene Rhythm
  • 00:14:32 Optimal Meal Timing, Tool: Extend Sleep-Related Fasts
  • 00:19:42 Eating Window Length, Tools: Adjusting TRE for Building Muscle, Regularity
  • 00:22:34 Accelerate Transition to Fasting, Glucose Clearing, Tool: After-Meal Walk
  • 00:24:16 Metformin, Berberine, Continuous Glucose Monitors; Cell Growth vs Repair, mTOR
  • 00:27:25 Gut Microbiome; Transitioning to Intermittent Fasting & Individualization
  • 00:29:43 Tool: 8-Hour Feeding Window & Weight Loss
  • 00:31:05 What Breaks a Fast?, Sugar; Tool: Using Salt to Support Fasting
  • 00:34:08 Tool: Ideal Feeding Window Guidelines; Exercise & Social Considerations

This transcript is currently under human review and may contain errors. The fully reviewed version will be posted as soon as it is available.

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Huberman Lab Essentials

Effects of Fasting & Time Restricted Eating on Fat Loss & Health

Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes.

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