Essentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson

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In this Huberman Lab Essentials episode, my guest is ⁠Dr. Matthew Johnson, PhD⁠, a senior researcher for the Center of Excellence for Psilocybin Research and Treatment at Sheppard Pratt’s Institute for Advanced Diagnostics and Therapeutics.

We explore the science and therapeutic potential of psychedelic medicine, including psilocybin, MDMA and LSD. We discuss how these substances can profoundly alter perception and self-identity, providing long-lasting relief from depression, addiction and trauma when used in controlled clinical settings. We also discuss microdosing and emerging research on psychedelics’ potential to support recovery from neurological injuries.

People Mentioned

  • Paul Stamets: mycologist, entrepreneur
  • David Olson: professor of chemistry, biochemistry and molecular medicine, UC Davis
  • Bryan Roth: professor of pharmacology, UNC School of Medicine
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  • 00:00:00 Matthew Johnson; Psychedelics
  • 00:01:44 Different Classes of Psychedelics
  • 00:04:33 Psychedelics & Altering Models
  • 00:06:18 LSD, Psylocibin & Serotonin
  • 00:08:44 Psychedelic Clinical Trials
  • 00:12:28 Therapy, Trust, Psychedelics
  • 00:15:36 Letting Go & Psychedelic Experience, Self-Representation, Lasting Changes
  • 00:21:19 MDMA, Dopamine & Serotonin; Bad Trips & Transcendental Experience
  • 00:24:43 Dangers of Psychedelics
  • 00:27:04 Microdosing Psychedelics, Antidepressant
  • 00:31:20 Head Injuries, Psychedelics, Depression

This transcript is currently under human review and may contain errors. The fully reviewed version will be posted as soon as it is available.

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Huberman Lab Essentials

Dr. Matthew Johnson: Psychedelic Medicine

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