Guest Episode
February 19, 2024

Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

Listen or watch on your favorite platforms

In this episode, my guest is Dr. Mark D'Esposito, M.D., a neurologist and professor of neuroscience and psychology at the University of California, Berkeley. We discuss the brain mechanisms underlying cognition and the forms of memory required for focus, productivity, planning and achieving goals, and learning. We discuss neurochemicals such as dopamine and acetylcholine and how they can be leveraged to improve cognitive functioning. We also discuss concussion, traumatic brain injury (TBI), Alzheimer's, and Parkinson's disease, and ways to restore or slow cognitive decline by using pharmacologic, lifestyle and behavioral protocols. This episode provides a modern understanding of cognition and memory and actionable tools to optimize brain health and function.

Journal Articles

Other Resources

Huberman Lab Episodes Mentioned

People Mentioned

About this Guest

Dr. Mark D'Esposito

Mark D'Esposito, M.D., is a neurologist and professor of neuroscience and psychology at the University of California, Berkeley.

  • 00:00:00 Dr. Mark D’Esposito
  • 00:02:08 Sponsors: Maui Nui, Joovv & Eight Sleep
  • 00:06:23 Brain & Frontal Lobes, Prefrontal Cortex, Executive Function
  • 00:10:31 Frontal Lobe Development, Children
  • 00:14:12 Rules, Context & Impulse Control; Learning & Goals
  • 00:21:45 Focus, Improving Executive Function
  • 00:26:04 Connections & Top-Down Signals
  • 00:29:02 Sponsor: AG1
  • 00:30:29 Frontal Lobe Injury; Emotional Regulation
  • 00:37:26 Smartphones, Social Media
  • 00:44:37 Working Memory, Dopamine
  • 00:52:59 Sponsor: LMNT
  • 00:54:22 Dopamine Levels & Working Memory, Cognitive Tasks, Genetics
  • 01:00:03 Bromocriptine & Working Memory, Dopamine
  • 01:06:21 Guanfacine, Neurotransmitter Levels, Pupil Dilation & Biomarker Tests
  • 01:12:46 Bromocriptine, Olympics; Pharmacology & Cognitive Function, Adderall
  • 01:19:27 Concussion, Traumatic Brain Injury (TBI)
  • 01:25:22 Sleep, TBI, Concussion & Executive Function; BrainHQ
  • 01:31:57 Aging & Frontal Executive System; Brain Health
  • 01:39:26 Tools: Brain Health & Boosting Executive Function, Books
  • 01:47:26 Alzheimer’s Disease, Genetics, Pharmacology
  • 01:51:48 Parkinson’s Disease, L-Dopa; Coping with Alzheimer’s; Nicotine
  • 01:58:37 Estrogen & Dopamine, Cognition; Tool: Physical Exercise
  • 02:04:43 Tool: Mindfulness Meditation & Executive Function
  • 02:10:31 Brain Networks; Modularity
  • 02:17:08 Modularity, Brain Indices
  • 02:22:53 Psilocybin; Transcranial Magnetic Stimulation
  • 02:30:16 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter

Become a Huberman Lab Premium member to access full episode transcripts & more

Members also get to submit questions for AMA episodes, plus access to exclusive bonus content. A significant portion of proceeds are donated to fund human scientific research.

Become a Member

or sign in to view this Transcript

No items found.

Join 500,000+ subscribers to get regular emails on neuroscience, health, and science-related tools from Dr. Andrew Huberman.

You'll also get Andrew's exclusive Daily Blueprint. In it, Andrew shares his daily routine. He also shares practical tools and protocols that you can use to stay productive and maximize your health.

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

By submitting your email to subscribe, you agree to Scicomm Media's Privacy Policy